A different form of chronic kidney disease which cannot be attributed to diabetes mellitus, hypertension, primary glomerular nephritis or other known etiologies has emerged in the North Central Region of Sri Lanka. This Chronic Kidney Disease of uncertain etiology (CKDu) is slowly progressive, probably starting in the second decade of life, and asymptomatic until very advanced. The North Central Region includes North Central Province and parts of Eastern, North Western and Uva Provinces. In these areas, CKDu has become a major public health problem causing devastating social economic and health impacts.

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